The Ultimate Guide To ceesdekker

The Ultimate Guide To ceesdekker

Blog Article

Making use of single-molecule optical and AFM imaging and drive-spectroscopy approaches, we find to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our exploration passions consist of:

It had been only in the nineties though, when nanotechnology had advanced into a level where solitary molecules could be manipulated, that the 1st experimental devices started to appear.

Multicolor imaging of your bacterial nucleoid and mobile division proteins with blue, orange, and in close proximity to-infrared fluorescent proteins

2007, to start with genuine-time detection of strand Trade in homologous recombination by RecA; discovery of the minimal persistence size of finishes of microtubules; and settled the system of biosensing with carbon nanotubes

2015, discovery that condensin is a really versatile protein construction; and first detection of DNA knots working with nanopores

The coiled-coil on the human Rad50 DNA restore protein is made up of particular segments of amplified versatility

We shape bacteria into forms that deviate from their natural phenotype. Precisely, I'll demonstrate our capability to shape Are living E. coli micro organism into novel designs including rectangles, squares, triangles and circles.

Dynamic ParB–DNA interactions initiate and retain a partition condensate for bacterial chromosome segregation

Imagine if, as opposed to using typical leading-down silicon electronics, transistors can be developed from The underside up making use of one natural molecules given that the switching factors? This concept, which became The idea of today’s subject of ceesdekker molecular electronics, initial emerged from the 1970s.

Bulk-area coupling identifies the mechanistic relationship between Min-protein patterns in vivo and in vitro

An integrated microfluidic platform for quantifying drug permeation throughout biomimetic vesicle membranes

Many new phenomena ended up found, and he and his research group established a number one position With this area of investigate. Dekker and his exploration group uncovered new physics of nanotubes in addition to explored the feasibility of molecular electronics. In 1998, they ended up the very first to make a transistor depending on only one nanotube molecule.

For instance, we look at the nucleopore elaborate, a gateway involving the cell nucleus and also the cytoplasm. This is a very intricate program and thus tricky to review within a cell, so we use biomimetics. We reconstruct holes and afterwards insert specific components of your nucleopore intricate to study transportation via it at The one-molecule degree.’

It absolutely was a really appealing time, during which I acquired loads of assistance from Delft University of Know-how, exactly where I used to be a professor at enough time, And that i begun a number of collaborations with molecular biologists. That aided me study a lot.’